product description
Bone regenerates---Decalcified human dental matrix material (DDM) is a bioactive bone-inducing material that can degrade and absorb bone morphogenetic protein (BMP).
Bone Regeneracy---Material of Decalcified Human Dentinal Matrix (DDM) is a kind of allogeneic material with bone morphogenetic protein (BMP) that can biodegrade and induce bone regenarrate by implantation.
Product advantages
1.Natural BMP compounds (Natural BMP compounds)：DDM is composed of collagen, BMP and hydroxyapatite, has osteoinductive activity, layered degradation, and guarantees high-quality osteogenesis for people of various physiques;
2.High porosity structure (High porosity)：porous and penetrating micro three-dimensional scaffold, excellent osteoconductivity, promote the adsorption and aggregation of cells and growth factors in the blood, provide a scaffold for the proliferation and differentiation of bone cells, and provide for cell growth and proliferation Suitable environment
3.Biodegradable：The degradation time is synchronized with the osteogenesis cycle, effectively controlling the sustained release of BMP;
4.High quality osteogenesis : Induce bone defect parts to differentiate again, rebuild and regenerate;
5.No rejection:DDM uses targeted hydrolysis and patented decellularization technology to remove immunogenicity, high biological safety, and no medical accidents or complaints have occurred so far.
Induction mechanism
When DDM is implanted into the body, the osteoinductive factor BMP contained in it performs signal transduction by combining with receptors and signal molecules in undifferentiated mesenchymal cells, and sends out gene regulation signals in the implantation area to induce mesenchymal cells. Differentiate into chondrocytes and bone cells. After the process of cartilage matrix precipitation, blood vessel growth, bone marrow and bone marrow cavity differentiation and formation, the formation of new bone is finally induced.
Clinical examples
Clinical examples
| Department |
gender |
age |
Classification |
Defect scope |
Material consumption (U) |
Bracket situation |
Local reaction |
Systemic reaction |
Effect |
| orthopedics |
Female |
54
|
Nonunion of humeral fracture |
2.4×2cm2
|
60×2
|
No |
No |
No |
Significantly effective |
| orthopedics |
|
32
|
Humeral bone tumor Bone defect |
0.5×2.5cm2
|
60
|
No |
No |
|
Significantly effective |
| neurosurgery |
male |
19
|
Lead bullet foreign body under the right forehead skull |
1.5×1.5cm2
|
120×2
|
No |
No |
No |
Significantly effective |
| neurosurgery |
male |
21
|
Left frontotemporal subdural intracerebral hematoma after surgery |
10×10 cm2
|
120×5
|
Titanium mesh |
No |
No |
|
| Stomatology |
Female |
35
|
Left mandibular cyst |
1.5×2cm2
|
30
|
No |
No |
No |
Significantly effective |
| Stomatology |
Female |
30
|
implanted teeth |
1.8×1.8cm2
|
30
|
No |
No |
No |
Significantly effective |
Indications
It is suitable for any occasion where bone grafting is required, including bone defect repair caused by various reasons.
Repair and treatment related to bone tissues such as fresh and old bone defects of various types of long bones and flat bones, and delayed healing.
